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Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control.

Publication ,  Journal Article
Biagas, KV; Hinton, VJ; Hasbani, NR; Luckett, PM; Wypij, D; Nadkarni, VM; Agus, MSD; HALF-PINT trial study investigators, ; PALISI Network,
Published in: J Pediatr
March 2020

OBJECTIVES: To investigate adaptive skills, behavior, and quality health-related quality of life in children from 32 centers enrolling in the Heart And Lung Failure-Pediatric INsulin Titration randomized controlled trial. STUDY DESIGN: This prospective longitudinal cohort study compared the effect of 2 tight glycemic control ranges (lower target, 80-100 mg/dL vs higher target, 150-180 mg/dL) 1-year neurobehavioral and health-related quality of life outcomes. Subjects had confirmed hyperglycemia and cardiac and/or respiratory failure. Patients aged 2-16 years old enrolled between April 2012 and September 2016 were studied at 1 year after intensive care discharge. The primary outcome, adaptive skills, was assessed using the Vineland Adaptive Behavior Scale. Behavior and health-related quality of life outcomes were assessed as secondary outcomes using the Pediatric Quality of Life and Child Behavior Checklist at baseline and 1-year follow-up. Group differences were evaluated using regression models adjusting for age category, baseline overall performance, and risk of mortality. RESULTS: Of 369 eligible children, 358 survived after hospital discharge and 214 (60%) completed follow-up. One-year Vineland Adaptive Behavior Scale-II composite scores were not different (mean ± SD, 79.9 ± 25.5 vs 79.4 ± 26.9, lower vs higher target; P = .20). Improvement in Pediatric Quality of Life total health from baseline was greater in the higher target group (adjusted mean difference, 8.2; 95% CI, 1.1-15.3; P = .02). CONCLUSIONS: One-year adaptive behavior in critically ill children with lower vs higher target glycemic control did not differ. The higher target group demonstrated improvement from baseline in overall health. This study affirms the lack of benefit of lower glucose targeting. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01565941.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

March 2020

Volume

218

Start / End Page

57 / 63.e5

Location

United States

Related Subject Headings

  • Time Factors
  • Quality of Life
  • Prospective Studies
  • Pediatrics
  • Neurodevelopmental Disorders
  • Male
  • Length of Stay
  • Intensive Care Units, Pediatric
  • Hyperglycemia
  • Humans
 

Citation

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Biagas, K. V., Hinton, V. J., Hasbani, N. R., Luckett, P. M., Wypij, D., Nadkarni, V. M., … PALISI Network, . (2020). Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. J Pediatr, 218, 57-63.e5. https://doi.org/10.1016/j.jpeds.2019.10.055
Biagas, Katherine V., Veronica J. Hinton, Natalie R. Hasbani, Peter M. Luckett, David Wypij, Vinay M. Nadkarni, Michael S. D. Agus, Michael S. D. HALF-PINT trial study investigators, and Michael S. D. PALISI Network. “Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control.J Pediatr 218 (March 2020): 57-63.e5. https://doi.org/10.1016/j.jpeds.2019.10.055.
Biagas KV, Hinton VJ, Hasbani NR, Luckett PM, Wypij D, Nadkarni VM, et al. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. J Pediatr. 2020 Mar;218:57-63.e5.
Biagas, Katherine V., et al. “Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control.J Pediatr, vol. 218, Mar. 2020, pp. 57-63.e5. Pubmed, doi:10.1016/j.jpeds.2019.10.055.
Biagas KV, Hinton VJ, Hasbani NR, Luckett PM, Wypij D, Nadkarni VM, Agus MSD, HALF-PINT trial study investigators, PALISI Network. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. J Pediatr. 2020 Mar;218:57-63.e5.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

March 2020

Volume

218

Start / End Page

57 / 63.e5

Location

United States

Related Subject Headings

  • Time Factors
  • Quality of Life
  • Prospective Studies
  • Pediatrics
  • Neurodevelopmental Disorders
  • Male
  • Length of Stay
  • Intensive Care Units, Pediatric
  • Hyperglycemia
  • Humans