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AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.

Publication ,  Journal Article
Liu, Y; Zhao, P; Cheng, M; Yu, L; Cheng, Z; Fan, L; Chen, C
Published in: Lipids Health Dis
December 3, 2018

BACKGROUND: Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of the major risk factors for cardiovascular disease, insulin resistance and metabolism syndrome. However, there are fewer investigations of the correlations between the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio and brachial ankle pulse wave velocity (baPWV). This study was undertaken to investigate the relationship between the AST to ALT ratio and brachial-ankle pulse wave velocity (baPWV) in a Japanese population. METHODS: The present study was a cross-sectional study. A total of 646 Japanese men and women without fatty liver, aged 24-84 years old, received a health medical check-up programme including the results from baPWV inspection and various standardized questionnaires in a health examination centre in Japan. Main outcome measures included AST/ALT ratio, baPWV, fatty liver and postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. A postmenopausal state was defined as beginning 1 year following the cessation of menses. RESULTS: After adjusting for potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise statuses, fatty liver, alcohol consumption and ABI), a non-linear relationship was detected between AST/ALT and baPWV, which had an inflection point of 5.6. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 12.7 (1.9 to 23.5) and - 16.7 (- 36.8 to 3.3), respectively. Subgroup analysis in participants with excessive alcohol consumption (more than 280 g/week) showed that AST/ALT had a negative correlation with baPWV (β = - 30.7, 95%CI (- 53.1, - 8.4)), and the P value for the interaction was less than 0.05. CONCLUSION: The relationship between AST/ALT and baPWV is non-linear. AST/ALT was positively correlated with baPWV when AST/ALT was less than 5.6. In addition, the trend was the opposite in subjects who consumed excessive amounts of alcohol.

Duke Scholars

Published In

Lipids Health Dis

DOI

EISSN

1476-511X

Publication Date

December 3, 2018

Volume

17

Issue

1

Start / End Page

275

Location

England

Related Subject Headings

  • Vascular Stiffness
  • Risk Factors
  • Pulse Wave Analysis
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatty Liver
  • Cardiovascular Diseases
 

Citation

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Liu, Y., Zhao, P., Cheng, M., Yu, L., Cheng, Z., Fan, L., & Chen, C. (2018). AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study. Lipids Health Dis, 17(1), 275. https://doi.org/10.1186/s12944-018-0920-4
Liu, Yongmei, Peiling Zhao, Mingliang Cheng, Lei Yu, Zhuo Cheng, Linda Fan, and Chi Chen. “AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.Lipids Health Dis 17, no. 1 (December 3, 2018): 275. https://doi.org/10.1186/s12944-018-0920-4.
Liu Y, Zhao P, Cheng M, Yu L, Cheng Z, Fan L, et al. AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study. Lipids Health Dis. 2018 Dec 3;17(1):275.
Liu, Yongmei, et al. “AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.Lipids Health Dis, vol. 17, no. 1, Dec. 2018, p. 275. Pubmed, doi:10.1186/s12944-018-0920-4.
Liu Y, Zhao P, Cheng M, Yu L, Cheng Z, Fan L, Chen C. AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study. Lipids Health Dis. 2018 Dec 3;17(1):275.
Journal cover image

Published In

Lipids Health Dis

DOI

EISSN

1476-511X

Publication Date

December 3, 2018

Volume

17

Issue

1

Start / End Page

275

Location

England

Related Subject Headings

  • Vascular Stiffness
  • Risk Factors
  • Pulse Wave Analysis
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatty Liver
  • Cardiovascular Diseases