Cellular senescence: from anti-cancer weapon to anti-aging target.

Journal Article (Journal Article;Review)

Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies described oncogene-induced senescence (OIS) as a barrier to tumorigenesis, such that the therapeutic induction of CS might represent a rational anti-cancer strategy. Indeed, the validity of this approach has been borne out by the development and approval of the cyclin-dependent kinase (CDK) inhibitor palbociclib for the treatment of breast cancer. Apart from tumors, senescent cells have also been shown to accumulate during natural mammalian aging, where they produce detrimental effects on the physiology of surrounding tissues. Thus, pharmacological senescent cell depletion has been proposed as an approach to delay age-related functional decline; this has been formally demonstrated in animal models. In this review article, we describe the current mechanistic understanding of cellular senescence at the molecular level and how it informs the development of new therapeutic strategies to combat cancer and aging.

Full Text

Duke Authors

Cited Authors

  • Yuan, L; Alexander, PB; Wang, X-F

Published Date

  • March 2020

Published In

Volume / Issue

  • 63 / 3

Start / End Page

  • 332 - 342

PubMed ID

  • 32060861

Electronic International Standard Serial Number (EISSN)

  • 1869-1889

Digital Object Identifier (DOI)

  • 10.1007/s11427-019-1629-6


  • eng

Conference Location

  • China