Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.

Journal Article (Journal Article)

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

Full Text

Duke Authors

Cited Authors

  • Durante, MA; Kurtenbach, S; Sargi, ZB; Harbour, JW; Choi, R; Kurtenbach, S; Goss, GM; Matsunami, H; Goldstein, BJ

Published Date

  • March 2020

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 323 - 326

PubMed ID

  • 32066986

Pubmed Central ID

  • PMC7065961

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/s41593-020-0587-9

Language

  • eng