Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism.


Journal Article

Neurons utilize mitochondrial oxidative phosphorylation (OxPhos) to generate energy essential for survival, function, and behavioral output. Unlike most cells that burn both fat and sugar, neurons only burn sugar. Despite its importance, how neurons meet the increased energy demands of complex behaviors such as learning and memory is poorly understood. Here we show that the estrogen-related receptor gamma (ERRγ) orchestrates the expression of a distinct neural gene network promoting mitochondrial oxidative metabolism that reflects the extraordinary neuronal dependence on glucose. ERRγ(-/-) neurons exhibit decreased metabolic capacity. Impairment of long-term potentiation (LTP) in ERRγ(-/-) hippocampal slices can be fully rescued by the mitochondrial OxPhos substrate pyruvate, functionally linking the ERRγ knockout metabolic phenotype and memory formation. Consistent with this notion, mice lacking neuronal ERRγ in cerebral cortex and hippocampus exhibit defects in spatial learning and memory. These findings implicate neuronal ERRγ in the metabolic adaptations required for memory formation.

Full Text

Duke Authors

Cited Authors

  • Pei, L; Mu, Y; Leblanc, M; Alaynick, W; Barish, GD; Pankratz, M; Tseng, TW; Kaufman, S; Liddle, C; Yu, RT; Downes, M; Pfaff, SL; Auwerx, J; Gage, FH; Evans, RM

Published Date

  • April 2015

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 628 - 636

PubMed ID

  • 25863252

Pubmed Central ID

  • 25863252

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

International Standard Serial Number (ISSN)

  • 1550-4131

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2015.03.004


  • eng