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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.

Publication ,  Journal Article
Hatori, M; Vollmers, C; Zarrinpar, A; DiTacchio, L; Bushong, EA; Gill, S; Leblanc, M; Chaix, A; Joens, M; Fitzpatrick, JAJ; Ellisman, MH; Panda, S
Published in: Cell metabolism
June 2012

While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.

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Published In

Cell metabolism

DOI

EISSN

1932-7420

ISSN

1550-4131

Publication Date

June 2012

Volume

15

Issue

6

Start / End Page

848 / 860

Related Subject Headings

  • Weight Gain
  • Time Factors
  • TOR Serine-Threonine Kinases
  • Ribosomal Protein S6 Kinases
  • Phosphorylation
  • Oxygen Consumption
  • Mice, Inbred C57BL
  • Mice
  • Metabolic Diseases
  • Male
 

Citation

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Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., … Panda, S. (2012). Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metabolism, 15(6), 848–860. https://doi.org/10.1016/j.cmet.2012.04.019
Hatori, Megumi, Christopher Vollmers, Amir Zarrinpar, Luciano DiTacchio, Eric A. Bushong, Shubhroz Gill, Mathias Leblanc, et al. “Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.Cell Metabolism 15, no. 6 (June 2012): 848–60. https://doi.org/10.1016/j.cmet.2012.04.019.
Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell metabolism. 2012 Jun;15(6):848–60.
Hatori, Megumi, et al. “Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.Cell Metabolism, vol. 15, no. 6, June 2012, pp. 848–60. Epmc, doi:10.1016/j.cmet.2012.04.019.
Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JAJ, Ellisman MH, Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell metabolism. 2012 Jun;15(6):848–860.
Journal cover image

Published In

Cell metabolism

DOI

EISSN

1932-7420

ISSN

1550-4131

Publication Date

June 2012

Volume

15

Issue

6

Start / End Page

848 / 860

Related Subject Headings

  • Weight Gain
  • Time Factors
  • TOR Serine-Threonine Kinases
  • Ribosomal Protein S6 Kinases
  • Phosphorylation
  • Oxygen Consumption
  • Mice, Inbred C57BL
  • Mice
  • Metabolic Diseases
  • Male