Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

Published

Journal Article

In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL function has not been determined. Here we have shown that Akt does not mediate IL-2- or TCR-induced cell metabolic responses; rather, this role is assumed by other Akt-related kinases. There is, however, a nonredundant role for sustained and strong activation of Akt in CTL to coordinate the TCR- and IL-2-induced transcriptional programs that control expression of key cytolytic effector molecules, adhesion molecules, and cytokine and chemokine receptors that distinguish effector versus memory and naive T cells. Akt is thus dispensable for metabolism, but the strength and duration of Akt activity dictates the CTL transcriptional program and determines CTL fate.

Full Text

Duke Authors

Cited Authors

  • Macintyre, AN; Finlay, D; Preston, G; Sinclair, LV; Waugh, CM; Tamas, P; Feijoo, C; Okkenhaug, K; Cantrell, DA

Published Date

  • February 25, 2011

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 224 - 236

PubMed ID

  • 21295499

Pubmed Central ID

  • 21295499

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2011.01.012

Language

  • eng

Conference Location

  • United States