Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

Journal Article (Journal Article)

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Full Text

Duke Authors

Cited Authors

  • Umuhire Juru, A; Cai, Z; Jan, A; Hargrove, AE

Published Date

  • March 2020

Published In

Volume / Issue

  • 56 / 24

Start / End Page

  • 3555 - 3558

PubMed ID

  • 32104839

Pubmed Central ID

  • PMC7218690

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/d0cc00266f


  • eng