Skip to main content

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial.

Publication ,  Journal Article
Dorling, JL; Das, SK; Racette, SB; Apolzan, JW; Zhang, D; Pieper, CF; Martin, CK; CALERIE Study Group,
Published in: Eur J Clin Nutr
August 2020

BACKGROUND/OBJECTIVES: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study showed that individuals who are nonobese were able to undergo significant calorie restriction (CR), yet the time course changes in adherence, weight, and appetite are unknown. This analysis aimed to investigate the time course changes in adherence, body weight, and appetite during the CALERIE study. SUBJECTS/METHODS: Overall, 143 participants (body mass index: 21.9-28.0 kg/m2) were randomized to a CR group that aimed to achieve 25% CR for 2 years. Throughout the intervention, body weight was measured, and appetite was assessed through visual analogue scales. Algorithms were utilized with body weight measurements to calculate adherence percentile score. Participants targeted an adherence percentile score of 50, though being between 80 (lowest acceptable adherence) and 10 (highest acceptable adherence) was adequate. Polynomial regression analyses were used to assess time course changes. RESULTS: Polynomials indicated that adherence percentile score increased above 50 after approximately week 20, although adherence remained acceptable (adherence percentile score less than 80) (R2 = 0.89; P < 0.001). Weight loss occurred until approximately week 60 and then plateaued (R2 ≥ 0.92; P < 0.001). Hunger and thirst increased (R2 ≥ 0.30; P < 0.001), but the total increase in scale scores were <10 mm throughout the intervention. CONCLUSIONS: In individuals who are nonobese, adherence to 25% CR declines after 20 weeks, but 2 years of CR that stimulates a meaningful reduction in weight, promotes aging-related benefits and negligibly affects appetite is viable.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur J Clin Nutr

DOI

EISSN

1476-5640

Publication Date

August 2020

Volume

74

Issue

8

Start / End Page

1210 / 1220

Location

England

Related Subject Headings

  • Weight Loss
  • Nutrition & Dietetics
  • Humans
  • Energy Intake
  • Caloric Restriction
  • Body Weight
  • Body Mass Index
  • Appetite
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dorling, J. L., Das, S. K., Racette, S. B., Apolzan, J. W., Zhang, D., Pieper, C. F., … CALERIE Study Group, . (2020). Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial. Eur J Clin Nutr, 74(8), 1210–1220. https://doi.org/10.1038/s41430-020-0593-8
Dorling, James L., Sai Krupa Das, Susan B. Racette, John W. Apolzan, Dachuan Zhang, Carl F. Pieper, Corby K. Martin, and Corby K. CALERIE Study Group. “Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial.Eur J Clin Nutr 74, no. 8 (August 2020): 1210–20. https://doi.org/10.1038/s41430-020-0593-8.
Dorling JL, Das SK, Racette SB, Apolzan JW, Zhang D, Pieper CF, et al. Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial. Eur J Clin Nutr. 2020 Aug;74(8):1210–20.
Dorling, James L., et al. “Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial.Eur J Clin Nutr, vol. 74, no. 8, Aug. 2020, pp. 1210–20. Pubmed, doi:10.1038/s41430-020-0593-8.
Dorling JL, Das SK, Racette SB, Apolzan JW, Zhang D, Pieper CF, Martin CK, CALERIE Study Group. Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial. Eur J Clin Nutr. 2020 Aug;74(8):1210–1220.

Published In

Eur J Clin Nutr

DOI

EISSN

1476-5640

Publication Date

August 2020

Volume

74

Issue

8

Start / End Page

1210 / 1220

Location

England

Related Subject Headings

  • Weight Loss
  • Nutrition & Dietetics
  • Humans
  • Energy Intake
  • Caloric Restriction
  • Body Weight
  • Body Mass Index
  • Appetite
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences