A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities.

Journal Article (Journal Article)

Radiotherapy is a critical component of many current, curative cancer treatments, yet it is accompanied by unavoidable irradiation of normal tissues. Abdominal and pelvic radiation almost always results in some dose delivered to the bowel with deleterious effects to the small and large intestines. While the likelihood of enteritis is dose dependent, there is also considerable variation between patients in both the extent of symptoms of enteritis as well as their duration. In this article, Martin and colleagues hypothesized that the radiation sensitivity of intestinal organoids could predict the sensitivity of individual patients to enteritis and have taken the first steps to develop such an assay.See related article by Martin et al., p. 1219.

Full Text

Duke Authors

Cited Authors

  • Muschel, RJ; Hammond, EM; Dewhirst, MW

Published Date

  • March 1, 2020

Published In

Volume / Issue

  • 80 / 5

Start / End Page

  • 927 - 928

PubMed ID

  • 32122905

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-19-4045


  • eng

Conference Location

  • United States