Instability in End-of-Life Care Preference Among Heart Failure Patients: Secondary Analysis of a Randomized Controlled Trial in Singapore.

Journal Article (Journal Article)


Efforts to improve quality of end-of-life (EOL) care are increasingly focused on eliciting patients' EOL preference through advance care planning (ACP). However, if patients' EOL preference changes over time and their ACP documents are not updated, these documents may no longer be valid at the time EOL decisions are made.


To assess extent and correlates of changes in stated preference for aggressive EOL care over time.


Secondary analysis of data from a randomized controlled trial of a formal ACP program versus usual care in Singapore.


Two hundred eighty-two patients with heart failure (HF) and New York Heart Association Classification III and IV symptoms were recruited and interviewed every 4 months for up to 2 years to assess their preference for EOL care. Analytic sample included 200 patients interviewed at least twice.


Nearly two thirds (64%) of patients changed their preferred type of EOL care at least once. Proportion of patients changing their stated preference for type of EOL care increased with time and the change was not unidirectional. Patients who understood their prognosis correctly were less likely to change their preference from non-aggressive to aggressive EOL care (OR 0.66, p value 0.07) or to prefer aggressive EOL care (OR 0.53; p value 0.001). On the other hand, patient-surrogate discussion of care preference was associated with a higher likelihood of change in patient preference from aggressive to non-aggressive EOL care (OR 1.83; p value 0.03).


The study provides evidence of instability in HF patients' stated EOL care preference. This undermines the value of an ACP document recorded months before EOL decisions are made unless a strategy exists for easily updating this preference.

Trial registration NCT02299180.

Full Text

Duke Authors

Cited Authors

  • Malhotra, C; Hu, M; Malhotra, R; Sim, D; Jaufeerally, FR; Bundoc, FG; Finkelstein, EA

Published Date

  • July 2020

Published In

Volume / Issue

  • 35 / 7

Start / End Page

  • 2010 - 2016

PubMed ID

  • 32103441

Pubmed Central ID

  • PMC7351942

Electronic International Standard Serial Number (EISSN)

  • 1525-1497

International Standard Serial Number (ISSN)

  • 0884-8734

Digital Object Identifier (DOI)

  • 10.1007/s11606-020-05740-2


  • eng