Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development.

Journal Article (Journal Article;Review)

Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.

Full Text

Duke Authors

Cited Authors

  • Roark, HK; Jenks, JA; Permar, SR; Schleiss, MR

Published Date

  • March 5, 2020

Published In

Volume / Issue

  • 221 / Suppl 1

Start / End Page

  • S60 - S73

PubMed ID

  • 32134481

Pubmed Central ID

  • PMC7057791

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiz484


  • eng

Conference Location

  • United States