Dawn of a New RAMPage.

Journal Article (Journal Article;Review)

Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implications upon their physiological and therapeutic potentials. Resurging interest in identifying RAMP-GPCR interactions has recently been fueled by coevolution studies and orthogonal technological screening platforms. These new studies reveal previously unrecognized RAMP-interacting GPCRs, many of which expand beyond Class B GPCRs. The consequences of these interactions on GPCR function and physiology lays the foundation for new molecular therapeutic targets, as evidenced by the recent success of erenumab. Here, we highlight recent papers that uncovered novel RAMP-GPCR interactions, human RAMP-GPCR disease-causing mutations, and RAMP-related human pathologies, paving the way for a new era of RAMP-targeted drug development.

Full Text

Duke Authors

Cited Authors

  • Serafin, DS; Harris, NR; Nielsen, NR; Mackie, DI; Caron, KM

Published Date

  • April 2020

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 249 - 265

PubMed ID

  • 32115276

Pubmed Central ID

  • PMC7236817

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2020.01.009


  • eng

Conference Location

  • England