Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.

Journal Article (Journal Article;Review)

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

Full Text

Duke Authors

Cited Authors

  • Tripathi, M; Yen, PM; Singh, BK

Published Date

  • February 28, 2020

Published In

Volume / Issue

  • 21 / 5

PubMed ID

  • 32121253

Pubmed Central ID

  • PMC7084735

Electronic International Standard Serial Number (EISSN)

  • 1422-0067

Digital Object Identifier (DOI)

  • 10.3390/ijms21051645


  • eng

Conference Location

  • Switzerland