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Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.

Publication ,  Journal Article
Tripathi, M; Yen, PM; Singh, BK
Published in: Int J Mol Sci
February 28, 2020

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

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Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

February 28, 2020

Volume

21

Issue

5

Location

Switzerland

Related Subject Headings

  • Receptors, Estrogen
  • Oxidation-Reduction
  • Molecular Targeted Therapy
  • Metabolic Diseases
  • Humans
  • Energy Metabolism
  • ERRalpha Estrogen-Related Receptor
  • Chemical Physics
  • Animals
  • 3404 Medicinal and biomolecular chemistry
 

Citation

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Tripathi, M., Yen, P. M., & Singh, B. K. (2020). Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. Int J Mol Sci, 21(5). https://doi.org/10.3390/ijms21051645
Tripathi, Madhulika, Paul Michael Yen, and Brijesh Kumar Singh. “Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.Int J Mol Sci 21, no. 5 (February 28, 2020). https://doi.org/10.3390/ijms21051645.
Tripathi, Madhulika, et al. “Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.Int J Mol Sci, vol. 21, no. 5, Feb. 2020. Pubmed, doi:10.3390/ijms21051645.

Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

February 28, 2020

Volume

21

Issue

5

Location

Switzerland

Related Subject Headings

  • Receptors, Estrogen
  • Oxidation-Reduction
  • Molecular Targeted Therapy
  • Metabolic Diseases
  • Humans
  • Energy Metabolism
  • ERRalpha Estrogen-Related Receptor
  • Chemical Physics
  • Animals
  • 3404 Medicinal and biomolecular chemistry