Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.
Publication
, Journal Article
Tripathi, M; Yen, PM; Singh, BK
Published in: Int J Mol Sci
February 28, 2020
The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.
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Published In
Int J Mol Sci
DOI
EISSN
1422-0067
Publication Date
February 28, 2020
Volume
21
Issue
5
Location
Switzerland
Related Subject Headings
- Receptors, Estrogen
- Oxidation-Reduction
- Molecular Targeted Therapy
- Metabolic Diseases
- Humans
- Energy Metabolism
- ERRalpha Estrogen-Related Receptor
- Chemical Physics
- Animals
- 3404 Medicinal and biomolecular chemistry
Citation
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ICMJE
MLA
NLM
Tripathi, M., Yen, P. M., & Singh, B. K. (2020). Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. Int J Mol Sci, 21(5). https://doi.org/10.3390/ijms21051645
Tripathi, Madhulika, Paul Michael Yen, and Brijesh Kumar Singh. “Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.” Int J Mol Sci 21, no. 5 (February 28, 2020). https://doi.org/10.3390/ijms21051645.
Tripathi M, Yen PM, Singh BK. Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. Int J Mol Sci. 2020 Feb 28;21(5).
Tripathi, Madhulika, et al. “Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.” Int J Mol Sci, vol. 21, no. 5, Feb. 2020. Pubmed, doi:10.3390/ijms21051645.
Tripathi M, Yen PM, Singh BK. Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. Int J Mol Sci. 2020 Feb 28;21(5).
Published In
Int J Mol Sci
DOI
EISSN
1422-0067
Publication Date
February 28, 2020
Volume
21
Issue
5
Location
Switzerland
Related Subject Headings
- Receptors, Estrogen
- Oxidation-Reduction
- Molecular Targeted Therapy
- Metabolic Diseases
- Humans
- Energy Metabolism
- ERRalpha Estrogen-Related Receptor
- Chemical Physics
- Animals
- 3404 Medicinal and biomolecular chemistry