Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.
Journal Article
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
Full Text
Duke Authors
Cited Authors
- Funk, RS; Talib, NJ; Zimmerman, KO; van Haandel, L; Becker, ML
Published Date
- June 2020
Published In
Volume / Issue
- 221 /
Start / End Page
- 235 - 239
PubMed ID
- 32111377
Pubmed Central ID
- PMC7247922
Electronic International Standard Serial Number (EISSN)
- 1097-6833
Digital Object Identifier (DOI)
- 10.1016/j.jpeds.2020.01.032
Language
- eng
Conference Location
- United States