Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.
Publication
, Journal Article
Funk, RS; Talib, NJ; Zimmerman, KO; van Haandel, L; Becker, ML
Published in: J Pediatr
June 2020
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
Duke Scholars
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Published In
J Pediatr
DOI
EISSN
1097-6833
Publication Date
June 2020
Volume
221
Start / End Page
235 / 239
Location
United States
Related Subject Headings
- Vitamin B Complex
- Sampling Studies
- Pilot Projects
- Pediatrics
- Methotrexate
- Humans
- Homeostasis
- Folic Acid
- Erythrocytes
- Down Syndrome
Citation
APA
Chicago
ICMJE
MLA
NLM
Funk, R. S., Talib, N. J., Zimmerman, K. O., van Haandel, L., & Becker, M. L. (2020). Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. J Pediatr, 221, 235–239. https://doi.org/10.1016/j.jpeds.2020.01.032
Funk, Ryan S., Nasreen J. Talib, Kanecia O. Zimmerman, Leon van Haandel, and Mara L. Becker. “Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.” J Pediatr 221 (June 2020): 235–39. https://doi.org/10.1016/j.jpeds.2020.01.032.
Funk RS, Talib NJ, Zimmerman KO, van Haandel L, Becker ML. Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. J Pediatr. 2020 Jun;221:235–9.
Funk, Ryan S., et al. “Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.” J Pediatr, vol. 221, June 2020, pp. 235–39. Pubmed, doi:10.1016/j.jpeds.2020.01.032.
Funk RS, Talib NJ, Zimmerman KO, van Haandel L, Becker ML. Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. J Pediatr. 2020 Jun;221:235–239.
Published In
J Pediatr
DOI
EISSN
1097-6833
Publication Date
June 2020
Volume
221
Start / End Page
235 / 239
Location
United States
Related Subject Headings
- Vitamin B Complex
- Sampling Studies
- Pilot Projects
- Pediatrics
- Methotrexate
- Humans
- Homeostasis
- Folic Acid
- Erythrocytes
- Down Syndrome