Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.

Journal Article

Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.

Full Text

Duke Authors

Cited Authors

  • Funk, RS; Talib, NJ; Zimmerman, KO; van Haandel, L; Becker, ML

Published Date

  • June 2020

Published In

Volume / Issue

  • 221 /

Start / End Page

  • 235 - 239

PubMed ID

  • 32111377

Pubmed Central ID

  • PMC7247922

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2020.01.032


  • eng

Conference Location

  • United States