Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma.

Journal Article (Journal Article)

Cells undergoing apoptosis are characterized by decreased cell size due to changes in intracellular ion concentration and rapid, aquaporin (AQP)-dependent water movement out of the cell, events required for the activation of pro-apoptotic enzymes. The current study demonstrates AQP 8 and 9 expression is significantly decreased in hepatocellular carcinoma (HCC) versus normal liver. Isolation of hepatic tumor cells (H4IIE) and hepatocytes confirmed a lack of water movement across the H4IIE cell membrane via AQPs and identified an inherent resistance of H4IIE cells to apoptotic stimuli. In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation.

Full Text

Duke Authors

Cited Authors

  • Jablonski, EM; Mattocks, MA; Sokolov, E; Koniaris, LG; Hughes, FM; Fausto, N; Pierce, RH; McKillop, IH

Published Date

  • May 18, 2007

Published In

Volume / Issue

  • 250 / 1

Start / End Page

  • 36 - 46

PubMed ID

  • 17084522

Pubmed Central ID

  • PMC1934939

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2006.09.013


  • eng

Conference Location

  • Ireland