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Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Publication ,  Journal Article
Hardin, M; Cho, MH; Sharma, S; Glass, K; Castaldi, PJ; McDonald, M-L; Aschard, H; Senter-Sylvia, J; Tantisira, K; Weiss, ST; Hersh, CP ...
Published in: Am J Respir Cell Mol Biol
March 2017

Chronic obstructive pulmonary disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. Sex-based genetic association studies may uncover additional COPD genetic risk factors. We studied current and former smokers from COPD case-control cohorts (COPDGene non-Hispanic whites and African Americans, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points, and Genetics of Chronic Obstructive Lung Disease). COPD was defined as post-bronchodilator forced expiratory volume in 1 second/forced vital capacity less than 0.70 and forced expiratory volume in 1 second percent predicted less than 80. Testing was performed across all cohorts and combined in a meta-analysis adjusted for age, pack-years, and genetic ancestry. We first performed genome-wide single-nucleotide polymorphism (SNP)-by-sex interaction testing on the outcome of COPD affection status. We performed sex-stratified association testing for SNPs with interaction P less than 10-6. We examined over 8 million SNPs in four populations, including 6,260 subjects with COPD (40.6% female) and 5,269 smoking control subjects (47.3% female). The SNP rs9615358 in the cadherin gene CELSR1 approached genome-wide significance for an interaction with sex (P = 1.24 × 10-7). In the sex-stratified meta-analysis, this SNP was associated with COPD among females (odds ratio, 1.37 [95% confidence interval, 1.25-1.49]; P = 3.32 × 10-7) but not males (odds ratio, 0.90 [95% confidence interval, 0.79-1.01]; P = 0.06). CELSR1 is involved in fetal lung development. In a human fetal lung tissue dataset, we observed greater CELSR1 expression in female compared with male samples. This SNP-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for COPD. Identifying sex-specific genetic risk factors may reveal new insights into sexually dimorphic features of COPD.

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Published In

Am J Respir Cell Mol Biol

DOI

EISSN

1535-4989

Publication Date

March 2017

Volume

56

Issue

3

Start / End Page

332 / 341

Location

United States

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lung
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
 

Citation

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Hardin, M., Cho, M. H., Sharma, S., Glass, K., Castaldi, P. J., McDonald, M.-L., … COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators, . (2017). Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol, 56(3), 332–341. https://doi.org/10.1165/rcmb.2016-0172OC
Hardin, Megan, Michael H. Cho, Sunita Sharma, Kimberly Glass, Peter J. Castaldi, Merry-Lynn McDonald, Hugues Aschard, et al. “Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.Am J Respir Cell Mol Biol 56, no. 3 (March 2017): 332–41. https://doi.org/10.1165/rcmb.2016-0172OC.
Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald M-L, et al. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 Mar;56(3):332–41.
Hardin, Megan, et al. “Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.Am J Respir Cell Mol Biol, vol. 56, no. 3, Mar. 2017, pp. 332–41. Pubmed, doi:10.1165/rcmb.2016-0172OC.
Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald M-L, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O’Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL, COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 Mar;56(3):332–341.

Published In

Am J Respir Cell Mol Biol

DOI

EISSN

1535-4989

Publication Date

March 2017

Volume

56

Issue

3

Start / End Page

332 / 341

Location

United States

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lung
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease