Cancer Survivorship and Subclinical Myocardial Damage.

Journal Article (Journal Article)

Cancer survivors might have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and a high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT) test results. We included 3,512 participants of the Atherosclerosis Risk in Communities Study who attended visit 5 (2011-2013) and were free of CVD (coronary heart disease, heart failure, or stroke). We used multivariate logistic regression to evaluate the cross-sectional associations of survivorship from any, non-sex-related, and sex-related cancers (e.g., breast, prostate) with elevated hs-cTnT (≥14 ng/L). Of 3,512 participants (mean age, 76 years; 62% women; 21% black), 19% were cancer survivors. Cancer survivors had significantly higher odds of elevated hs-cTnT (OR = 1.26, 95% CI: 1.03, 1.53). Results were similar for survivors of non-sex-related and colorectal cancers, but there was no association between survivorship from breast and prostate cancers and elevated hs-cTnT. Results were similar after additional adjustments for CVD risk factors. Survivors of some cancers might be more likely to have elevated hs-cTnT than persons without prior cancer. The excess burden of subclinical myocardial damage in this population might not be fully explained by traditional CVD risk factors.

Full Text

Duke Authors

Cited Authors

  • Florido, R; Lee, AK; McEvoy, JW; Hoogeveen, RC; Koton, S; Vitolins, MZ; Shenoy, C; Russell, SD; Blumenthal, RS; Ndumele, CE; Ballantyne, CM; Joshu, CE; Platz, EA; Selvin, E

Published Date

  • December 31, 2019

Published In

Volume / Issue

  • 188 / 12

Start / End Page

  • 2188 - 2195

PubMed ID

  • 30927355

Pubmed Central ID

  • PMC7212406

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

Digital Object Identifier (DOI)

  • 10.1093/aje/kwz088


  • eng

Conference Location

  • United States