The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata.

Journal Article (Journal Article)

BACKGROUND: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. OBJECTIVE: To produce an international consensus statement on the use and utility of various treatments for AA. METHODS: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. RESULTS: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. LIMITATIONS: The study included a comprehensive list of systemic treatments for AA but not all treatments used. CONCLUSION: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.

Full Text

Duke Authors

Cited Authors

  • Meah, N; Wall, D; York, K; Bhoyrul, B; Bokhari, L; Sigall, DA; Bergfeld, WF; Betz, RC; Blume-Peytavi, U; Callender, V; Chitreddy, V; Combalia, A; Cotsarelis, G; Craiglow, B; Donovan, J; Eisman, S; Farrant, P; Green, J; Grimalt, R; Harries, M; Hordinsky, M; Irvine, AD; Itami, S; Jolliffe, V; King, B; Lee, W-S; McMichael, A; Messenger, A; Mirmirani, P; Olsen, E; Orlow, SJ; Piraccini, BM; Rakowska, A; Reygagne, P; Roberts, JL; Rudnicka, L; Shapiro, J; Sharma, P; Tosti, A; Vogt, A; Wade, M; Yip, L; Zlotogorski, A; Sinclair, R

Published Date

  • July 2020

Published In

Volume / Issue

  • 83 / 1

Start / End Page

  • 123 - 130

PubMed ID

  • 32165196

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2020.03.004


  • eng

Conference Location

  • United States