A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.

Journal Article (Journal Article)

Separation of nano/microparticles based on surface acoustic waves (SAWs) has shown great promise for biological, chemical, and medical applications ranging from sample purification to cancer diagnosis. However, the permanent bonding of a microchannel onto relatively expensive piezoelectric substrates and excitation transducers renders the SAW separation devices non-disposable. This limitation not only requires cumbersome cleaning and increased labor and material costs, but also leads to cross-contamination, preventing their implementation in many biological, chemical, and medical applications. Here, we demonstrate a high-performance, disposable acoustofluidic platform for nano/microparticle separation. Leveraging unidirectional interdigital transducers (IDTs), a hybrid channel design with hard/soft materials, and tilted-angle standing SAWs (taSSAWs), our disposable acoustofluidic devices achieve acoustic radiation forces comparable to those generated by existing permanently bonded, non-disposable devices. Our disposable devices can separate not only microparticles but also nanoparticles. Moreover, they can differentiate bacteria from human red blood cells (RBCs) with a purity of up to 96%. Altogether, we developed a unidirectional IDT-based, disposable acoustofluidic platform for micro/nanoparticle separation that can achieve high separation efficiency, versatility, and biocompatibility.

Full Text

Duke Authors

Cited Authors

  • Zhao, S; Wu, M; Yang, S; Wu, Y; Gu, Y; Chen, C; Ye, J; Xie, Z; Tian, Z; Bachman, H; Huang, P-H; Xia, J; Zhang, P; Zhang, H; Huang, TJ

Published Date

  • April 2020

Published In

Volume / Issue

  • 20 / 7

Start / End Page

  • 1298 - 1308

PubMed ID

  • 32195522

Pubmed Central ID

  • PMC7199844

Electronic International Standard Serial Number (EISSN)

  • 1473-0189

International Standard Serial Number (ISSN)

  • 1473-0197

Digital Object Identifier (DOI)

  • 10.1039/d0lc00106f

Language

  • eng