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A consensus-based framework for conducting and reporting osteoarthritis phenotype research.

Publication ,  Journal Article
van Spil, WE; Bierma-Zeinstra, SMA; Deveza, LA; Arden, NK; Bay-Jensen, A-C; Kraus, VB; Carlesso, L; Christensen, R; Van Der Esch, M; Kent, P ...
Published in: Arthritis Res Ther
March 20, 2020

BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, a wide range of views exist on how best to operationalize this concept. The current project aimed to provide consensus-based definitions and recommendations that together create a framework for conducting and reporting OA phenotype research. METHODS: A panel of 25 members with expertise in OA phenotype research was composed. First, panel members participated in an online Delphi exercise to provide a number of basic definitions and statements relating to OA phenotypes and OA phenotype research. Second, panel members provided input on a set of recommendations for reporting on OA phenotype studies. RESULTS: Four Delphi rounds were required to achieve sufficient agreement on 11 definitions and statements. OA phenotypes were defined as subtypes of OA that share distinct underlying pathobiological and pain mechanisms and their structural and functional consequences. Reporting recommendations pertaining to the study characteristics, study population, data collection, statistical analysis, and appraisal of OA phenotype studies were provided. CONCLUSIONS: This study provides a number of consensus-based definitions and recommendations relating to OA phenotypes. The resulting framework is intended to facilitate research on OA phenotypes and increase combined efforts to develop effective OA phenotype classification. Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.

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Published In

Arthritis Res Ther

DOI

EISSN

1478-6362

Publication Date

March 20, 2020

Volume

22

Issue

1

Start / End Page

54

Location

England

Related Subject Headings

  • Research Report
  • Practice Guidelines as Topic
  • Phenotype
  • Outcome Assessment, Health Care
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Humans
  • Delphi Technique
  • Consensus
  • Biomedical Research
 

Citation

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van Spil, W. E., Bierma-Zeinstra, S. M. A., Deveza, L. A., Arden, N. K., Bay-Jensen, A.-C., Kraus, V. B., … Hunter, D. J. (2020). A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Res Ther, 22(1), 54. https://doi.org/10.1186/s13075-020-2143-0
Spil, W. E. van, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A. -. C. Bay-Jensen, V Byers Kraus, L. Carlesso, et al. “A consensus-based framework for conducting and reporting osteoarthritis phenotype research.Arthritis Res Ther 22, no. 1 (March 20, 2020): 54. https://doi.org/10.1186/s13075-020-2143-0.
van Spil WE, Bierma-Zeinstra SMA, Deveza LA, Arden NK, Bay-Jensen A-C, Kraus VB, et al. A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Res Ther. 2020 Mar 20;22(1):54.
van Spil, W. E., et al. “A consensus-based framework for conducting and reporting osteoarthritis phenotype research.Arthritis Res Ther, vol. 22, no. 1, Mar. 2020, p. 54. Pubmed, doi:10.1186/s13075-020-2143-0.
van Spil WE, Bierma-Zeinstra SMA, Deveza LA, Arden NK, Bay-Jensen A-C, Kraus VB, Carlesso L, Christensen R, Van Der Esch M, Kent P, Knoop J, Ladel C, Little CB, Loeser RF, Losina E, Mills K, Mobasheri A, Nelson AE, Neogi T, Peat GM, Rat A-C, Steultjens M, Thomas MJ, Valdes AM, Hunter DJ. A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Res Ther. 2020 Mar 20;22(1):54.

Published In

Arthritis Res Ther

DOI

EISSN

1478-6362

Publication Date

March 20, 2020

Volume

22

Issue

1

Start / End Page

54

Location

England

Related Subject Headings

  • Research Report
  • Practice Guidelines as Topic
  • Phenotype
  • Outcome Assessment, Health Care
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Humans
  • Delphi Technique
  • Consensus
  • Biomedical Research