Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults.

Journal Article (Journal Article)

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatologists, ophthalmologists, intensivists, and gynecologists with expertise in SJS/TEN to generate statements for supportive care guideline development. Members of the Society of Dermatology Hospitalists with expertise in SJS/TEN were invited to participate in a modified, online Delphi-consensus. Participants were administered 9-point Likert scale questionnaires regarding 135 statements. The RAND/UCLA Appropriateness Method was used to evaluate and select proposed statements for guideline inclusion; statements with median ratings of 6.5 to 9 and a disagreement index of ≤1 were included in the guideline. For the final round, the guidelines were appraised by all of the participants. Included are an evidence-based discussion and recommendations for hospital setting and care team, wound care, ocular care, oral care, urogenital care, pain management, infection surveillance, fluid and electrolyte management, nutrition and stress ulcer prophylaxis, airway management, and anticoagulation in adult patients with SJS/TEN.

Full Text

Duke Authors

Cited Authors

  • Seminario-Vidal, L; Kroshinsky, D; Malachowski, SJ; Sun, J; Markova, A; Beachkofsky, TM; Kaffenberger, BH; Ergen, EN; Mauskar, M; Bridges, A; Calhoun, C; Cardones, AR; Chen, ST; Chodosh, J; Cotliar, J; Davis, MDP; DeNiro, KL; Dominguez, AR; Eljure-Téllez, J; Femia, A; Fox, LP; Guda, A; Mitchell, C; Mostaghimi, A; Ortega-Loayza, AG; Owen, C; Pasieka, H; Rahnama-Moghadam, S; Saeed, HN; Saunderson, RB; Shanbhag, S; Sharon, VR; Strowd, L; Venkatesh, S; Wanat, KA; Wetter, DA; Worswick, S; Micheletti, RG

Published Date

  • June 2020

Published In

Volume / Issue

  • 82 / 6

Start / End Page

  • 1553 - 1567

PubMed ID

  • 32151629

Pubmed Central ID

  • 32151629

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2020.02.066


  • eng

Conference Location

  • United States