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Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening.

Publication ,  Journal Article
Rohner, E; McGuire, FH; Liu, Y; Li, Q; Miele, K; Desai, SA; Schmitt, JW; Knittel, A; Nelson, JAE; Edelman, C; Sivaraman, V; Baker, A ...
Published in: J Womens Health (Larchmt)
July 2020

Background: We compared women's acceptability of urine and cervico-vaginal sample self-collection for high-risk (oncogenic) human papillomavirus (hrHPV) testing and assessed whether acceptability varied across racial/ethnic groups. Methods: As part of a test accuracy study of urine-based hrHPV testing, we recruited a convenience sample of women 25-65 years of age at two colposcopy clinics in North Carolina between November 2016 and January 2019. After self-collection of urine and cervico-vaginal samples, women completed a questionnaire on the acceptability of the sample collection methods. We coded open-ended questions inductively. All results are presented stratified by racial/ethnic group. Results: We included 410 women (119 Hispanic, 115 non-Hispanic Black, 154 non-Hispanic White, and 22 women with other racial identities). Most women (79%, 95% confidence interval [CI] = 76%-83%) had positive feelings about urine-based hrHPV testing. Women generally preferred urine (78%, 95% CI = 74%-82%) over cervico-vaginal self-collection (18%, 95% CI = 14%-22%), but the degree differed by racial/ethnic group, increasing from 75% in non-Hispanic Black to 82% in Hispanic women (p = 0.011). Most women reported at least one positive aspect of urine (89%) and cervico-vaginal self-collection (85%) for hrHPV testing with the most common positive aspect being easy sample collection, although 16% of women were concerned about performing the cervico-vaginal self-collection correctly. Conclusions: Self-collection for hrHPV-based cervical cancer screening is highly acceptable to women across different racial/ethnic groups in the United States, and most women in our study would be more likely to attend future cervical cancer screening appointments if screening were urine based. Urine-based hrHPV testing is a promising approach to improve cervical cancer screening coverage.

Duke Scholars

Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

July 2020

Volume

29

Issue

7

Start / End Page

971 / 979

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Vagina
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Urinalysis
  • Surveys and Questionnaires
  • Specimen Handling
  • Self-Examination
  • Reproducibility of Results
  • Public Health
 

Citation

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MLA
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Rohner, E., McGuire, F. H., Liu, Y., Li, Q., Miele, K., Desai, S. A., … Smith, J. S. (2020). Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening. J Womens Health (Larchmt), 29(7), 971–979. https://doi.org/10.1089/jwh.2019.8132
Rohner, Eliane, F Hunter McGuire, Yutong Liu, Quefeng Li, Kate Miele, Samveg A. Desai, John W. Schmitt, et al. “Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening.J Womens Health (Larchmt) 29, no. 7 (July 2020): 971–79. https://doi.org/10.1089/jwh.2019.8132.
Rohner E, McGuire FH, Liu Y, Li Q, Miele K, Desai SA, et al. Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening. J Womens Health (Larchmt). 2020 Jul;29(7):971–9.
Rohner, Eliane, et al. “Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening.J Womens Health (Larchmt), vol. 29, no. 7, July 2020, pp. 971–79. Pubmed, doi:10.1089/jwh.2019.8132.
Rohner E, McGuire FH, Liu Y, Li Q, Miele K, Desai SA, Schmitt JW, Knittel A, Nelson JAE, Edelman C, Sivaraman V, Baker A, Romocki LS, Rahangdale L, Smith JS. Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening. J Womens Health (Larchmt). 2020 Jul;29(7):971–979.
Journal cover image

Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

July 2020

Volume

29

Issue

7

Start / End Page

971 / 979

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Vagina
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Urinalysis
  • Surveys and Questionnaires
  • Specimen Handling
  • Self-Examination
  • Reproducibility of Results
  • Public Health