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Prognostic factors affecting mortality in patients with esophageal GISTs.

Publication ,  Journal Article
Schizas, D; Bagias, G; Kanavidis, P; Moris, D; Spartalis, E; Damaskos, C; Garmpis, N; Karavokyros, I; P Misiakos, E; Liakakos, T
Published in: Journal of B.U.ON. : official journal of the Balkan Union of Oncology
January 2020

Esophageal gastrointestinal stromal tumors (GISTs) compose a very rare clinical entity, representing 0.7% of all GISTs. Therefore, the clinicopathological factors that affect mortality are currently not adequately examined. We reviewed individual cases of esophageal GISTs found in the literature in order to identify the prognostic factors affecting mortality.MEDLINE, EMBASE, and the Cochrane Library were systematically searched to identify clinical studies and case reports referring to esophageal GISTs. The clinicopathological features were recorded and evaluated.A total number of 105 patients were found. The median age of patients was 58 years (mean 52.4%). The majority of patients (71.6%) presented with tumor-associated symptoms. Tumors were mostly located at the lower esophagus (72.9%), and the median tumor size was 7 cm. Esophagectomy was the most common surgical approach (54.3%), followed by tumor enucleation (45.7%). The median follow-up period was 34 months; tumor recurrence occurred in 18 cases (18.9%) and 19 died of disease (19.2%). The overall survival rate was 75.8%. We found out that tumor size and high mitotic rate (>10 mitosis per hpf) were significant prognostic factors for survival. Presence of symptoms, ulceration, and tumor necrosis as well as tumor recurrence were also significant prognostic factors (p<0.01).Esophageal GISTs' tumor size and mitotic rate are the most significant factors for survival. For dubious cases, a pre-operative biopsy can auspiciously establish the diagnosis of an esophageal GIST. Regarding surgical treatment, tumor enucleation can be safely and feasibly performed for relatively small, intact tumors, whereas large, aggressive tumors are resected with radical esophagectomy.

Duke Scholars

Published In

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

EISSN

2241-6293

ISSN

1107-0625

Publication Date

January 2020

Volume

25

Issue

1

Start / End Page

497 / 507

Related Subject Headings

  • Survival Analysis
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Gastrointestinal Stromal Tumors
  • Female
  • Esophageal Neoplasms
 

Citation

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Schizas, D., Bagias, G., Kanavidis, P., Moris, D., Spartalis, E., Damaskos, C., … Liakakos, T. (2020). Prognostic factors affecting mortality in patients with esophageal GISTs. Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, 25(1), 497–507.
Schizas, Dimitrios, George Bagias, Prodromos Kanavidis, Demetrios Moris, Eleftherios Spartalis, Christos Damaskos, Nikolaos Garmpis, Ioannis Karavokyros, Evangelos P Misiakos, and Theodore Liakakos. “Prognostic factors affecting mortality in patients with esophageal GISTs.Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology 25, no. 1 (January 2020): 497–507.
Schizas D, Bagias G, Kanavidis P, Moris D, Spartalis E, Damaskos C, et al. Prognostic factors affecting mortality in patients with esophageal GISTs. Journal of BUON : official journal of the Balkan Union of Oncology. 2020 Jan;25(1):497–507.
Schizas, Dimitrios, et al. “Prognostic factors affecting mortality in patients with esophageal GISTs.Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, vol. 25, no. 1, Jan. 2020, pp. 497–507.
Schizas D, Bagias G, Kanavidis P, Moris D, Spartalis E, Damaskos C, Garmpis N, Karavokyros I, P Misiakos E, Liakakos T. Prognostic factors affecting mortality in patients with esophageal GISTs. Journal of BUON : official journal of the Balkan Union of Oncology. 2020 Jan;25(1):497–507.

Published In

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

EISSN

2241-6293

ISSN

1107-0625

Publication Date

January 2020

Volume

25

Issue

1

Start / End Page

497 / 507

Related Subject Headings

  • Survival Analysis
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Gastrointestinal Stromal Tumors
  • Female
  • Esophageal Neoplasms