Impact of treatment modality on quality of life of head and neck cancer patients: Findings from an academic medical institution.

Journal Article (Journal Article)

PURPOSE: The objective of this pilot study was to determine how different treatment modalities (surgery, radiation, and chemotherapy) impact quality of life (QOL) in a population of head and neck cancer (HNC) survivors. METHODS: Fifty-nine newly diagnosed, biopsy-confirmed HNC patients were recruited between 2007-2012. They completed the EORTC Quality of Life Questionnaire and Head & Neck Module at 5 intervals pre- and post-treatment. Participants were grouped into four categories based on modality: surgery only, surgery/radiation, chemoradiation, or surgery/chemoradiation. Repeated measures ANOVA examined effect of treatment modality on QOL over time. RESULTS: Xerostomia symptoms were significantly associated with chemoradiation (F(2.47, 59.27)=3.57, p=0.03), lowest at pretreatment and highest 6 months post-treatment. Time was significantly associated with head and neck pain, F(2.95,67.89)=3.39, p=0.02. CONCLUSIONS: HNC survivors exhibit different QOL related symptoms depending on combined treatment modalities, and time post-treatment. It is important to understand QOL differences based upon treatment modalities when developing treatment plans for HNC patients.

Full Text

Duke Authors

Cited Authors

  • Christopher, KM; Osazuwa-Peters, N; Dougherty, R; Indergaard, SA; Popp, C; Walker, R; Varvares, MA

Published Date

  • 2017

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 168 - 173

PubMed ID

  • 28081981

Electronic International Standard Serial Number (EISSN)

  • 1532-818X

Digital Object Identifier (DOI)

  • 10.1016/j.amjoto.2016.12.003


  • eng

Conference Location

  • United States