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Right and left ventricular diastolic pressure-volume relations: a comprehensive review.

Publication ,  Journal Article
Pasipoularides, A
Published in: J Cardiovasc Transl Res
April 2013

Ventricular compliance alterations can affect cardiac performance and adaptations. Moreover, diastolic mechanics are important in assessing both diastolic and systolic function, since any filling impairment can compromise systolic function. A sigmoidal passive filling pressure-volume relationship, developed using chronically instrumented, awake-animal disease models, is clinically adaptable to evaluating diastolic dynamics using subject-specific micromanometric and volumetric data from the entire filling period of any heartbeat(s). This innovative relationship is the global, integrated expression of chamber geometry, wall thickness, and passive myocardial wall properties. Chamber and myocardial compliance curves of both ventricles can be computed by the sigmoidal methodology over the entire filling period and plotted over appropriate filling pressure ranges. Important characteristics of the compliance curves can be examined and compared between the right and the left ventricle and for different physiological and pathological conditions. The sigmoidal paradigm is more accurate and, therefore, a better alternative to the conventional exponential pressure-volume approximation.

Duke Scholars

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2013

Volume

6

Issue

2

Start / End Page

239 / 252

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Stroke Volume
  • Models, Cardiovascular
  • Humans
  • Heart Rate
  • Diastole
  • Compliance
  • Biomechanical Phenomena
 

Citation

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Pasipoularides, A. (2013). Right and left ventricular diastolic pressure-volume relations: a comprehensive review. J Cardiovasc Transl Res, 6(2), 239–252. https://doi.org/10.1007/s12265-012-9424-1
Pasipoularides, Ares. “Right and left ventricular diastolic pressure-volume relations: a comprehensive review.J Cardiovasc Transl Res 6, no. 2 (April 2013): 239–52. https://doi.org/10.1007/s12265-012-9424-1.
Pasipoularides A. Right and left ventricular diastolic pressure-volume relations: a comprehensive review. J Cardiovasc Transl Res. 2013 Apr;6(2):239–52.
Pasipoularides, Ares. “Right and left ventricular diastolic pressure-volume relations: a comprehensive review.J Cardiovasc Transl Res, vol. 6, no. 2, Apr. 2013, pp. 239–52. Pubmed, doi:10.1007/s12265-012-9424-1.
Pasipoularides A. Right and left ventricular diastolic pressure-volume relations: a comprehensive review. J Cardiovasc Transl Res. 2013 Apr;6(2):239–252.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2013

Volume

6

Issue

2

Start / End Page

239 / 252

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Stroke Volume
  • Models, Cardiovascular
  • Humans
  • Heart Rate
  • Diastole
  • Compliance
  • Biomechanical Phenomena