Skip to main content

Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study.

Publication ,  Journal Article
Wang, Y; Jafar, TH; Jin, A; Yuan, J-M; Koh, W-P
Published in: Nutrition and cancer
January 2021

Background: Epidemiological studies have demonstrated separately that patients with kidney stone may have higher dietary intake of zinc and higher risk of developing kidney cancer. We prospectively assessed the associations of dietary zinc and other trace elements with kidney cancer risk for the first time.Methods: We used data from the prospective Singapore Chinese Health Study that recruited 63,257 adult Chinese residing in Singapore between 1993 and 1998. A validated food frequency questionnaire and the Singapore Food Composition Database was used to compute the values of intake for zinc, copper and manganese. We identified incident cancer cases via linkage with nationwide cancer registry, and used Cox proportional hazard models to compute hazard ratio (HR) and 95% confidence interval (CI) for the association with kidney cancer risk.Results: There were 229 incident kidney cancer cases after median follow-up of 20.1 years. Dietary zinc intake was positively associated with higher kidney cancer risk; the HR comparing the extreme quartiles of zinc intake was 1.74 (95% CI: 1.02-2.97; P-trend = 0.033). Conversely, intakes of copper and manganese were not associated with kidney cancer risk.Conclusions: The positive association between dietary zinc and risk of kidney cancer suggests that zinc may be implicated in renal carcinogenesis.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nutrition and cancer

DOI

EISSN

1532-7914

ISSN

0163-5581

Publication Date

January 2021

Volume

73

Issue

2

Start / End Page

239 / 245

Related Subject Headings

  • Trace Elements
  • Singapore
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Kidney Neoplasms
  • Humans
  • Eating
  • China
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, Y., Jafar, T. H., Jin, A., Yuan, J.-M., & Koh, W.-P. (2021). Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study. Nutrition and Cancer, 73(2), 239–245. https://doi.org/10.1080/01635581.2020.1743870
Wang, Yeli, Tazeen H. Jafar, Aizhen Jin, Jian-Min Yuan, and Woon-Puay Koh. “Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study.Nutrition and Cancer 73, no. 2 (January 2021): 239–45. https://doi.org/10.1080/01635581.2020.1743870.
Wang Y, Jafar TH, Jin A, Yuan J-M, Koh W-P. Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study. Nutrition and cancer. 2021 Jan;73(2):239–45.
Wang, Yeli, et al. “Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study.Nutrition and Cancer, vol. 73, no. 2, Jan. 2021, pp. 239–45. Epmc, doi:10.1080/01635581.2020.1743870.
Wang Y, Jafar TH, Jin A, Yuan J-M, Koh W-P. Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study. Nutrition and cancer. 2021 Jan;73(2):239–245.

Published In

Nutrition and cancer

DOI

EISSN

1532-7914

ISSN

0163-5581

Publication Date

January 2021

Volume

73

Issue

2

Start / End Page

239 / 245

Related Subject Headings

  • Trace Elements
  • Singapore
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Kidney Neoplasms
  • Humans
  • Eating
  • China