Availability and scope of integrated screening for patients with Lynch syndrome.

Journal Article (Journal Article)

OBJECTIVE: To assess the availability and capacity of US-based integrated centers for the management of Lynch syndrome. METHODS: A cross-sectional survey of practice patterns in the care of patients with Lynch syndrome was conducted at 33 National Cancer Institute-designated cancer centers in the USA from March 1 to June 1, 2013. Each cancer center was contacted by telephone and the caller used a uniform scripted greeting and survey format. RESULTS: All centers routinely recommended colonoscopy. Other recommended screening modalities were hysterectomy and bilateral salpingo-oophorectomy (29/33; 88%), endoscopy (27/33; 82%), urinalysis (23/33; 70%), endometrial sampling (21/33; 64%), dermatologic examination (19/32; 59%), pelvic ultrasonography (18/33; 55%), serum CA125 level (14/33; 42%), urine cytology (14/33; 42%), computed tomography (1/33; 3%), and magnetic resonance imaging (1/33; 3%). Each center had a multidisciplinary team but the composition varied. A designated team leader was present at 21 centers (64%). Having a team leader was associated with an increased likelihood of recommending endoscopy (P=0.04) and dermatologic surveillance (P=0.01). Only 23 centers (70%) had a system in place for communicating follow-up with patients. CONCLUSION: The lack of consensus in practice patterns recorded among participating centers probably reflected the limited existing evidence on the usefulness of most screening modalities.

Full Text

Duke Authors

Cited Authors

  • Frey, MK; Pauk, SJ; Caputo, TA; Moss, HA; Sapra, KJ; Gerber, D; Stewart, JD

Published Date

  • November 2015

Published In

Volume / Issue

  • 131 / 2

Start / End Page

  • 142 - 146

PubMed ID

  • 26365573

Pubmed Central ID

  • 26365573

Electronic International Standard Serial Number (EISSN)

  • 1879-3479

Digital Object Identifier (DOI)

  • 10.1016/j.ijgo.2015.05.023


  • eng

Conference Location

  • United States