Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene.
Journal Article (Journal Article)
We identified adpA as an araC-like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene (bldA). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions.
Full Text
Duke Authors
Cited Authors
- Nguyen, KT; Tenor, J; Stettler, H; Nguyen, LT; Nguyen, LD; Thompson, CJ
Published Date
- December 2003
Published In
Volume / Issue
- 185 / 24
Start / End Page
- 7291 - 7296
PubMed ID
- 14645292
Pubmed Central ID
- PMC296263
International Standard Serial Number (ISSN)
- 0021-9193
Digital Object Identifier (DOI)
- 10.1128/JB.185.24.7291-7296.2003
Language
- eng
Conference Location
- United States