Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene.

Journal Article (Journal Article)

We identified adpA as an araC-like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene (bldA). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions.

Full Text

Duke Authors

Cited Authors

  • Nguyen, KT; Tenor, J; Stettler, H; Nguyen, LT; Nguyen, LD; Thompson, CJ

Published Date

  • December 2003

Published In

Volume / Issue

  • 185 / 24

Start / End Page

  • 7291 - 7296

PubMed ID

  • 14645292

Pubmed Central ID

  • PMC296263

International Standard Serial Number (ISSN)

  • 0021-9193

Digital Object Identifier (DOI)

  • 10.1128/JB.185.24.7291-7296.2003


  • eng

Conference Location

  • United States