Photo-released drugs: A targeted treatment approach for arthritis

Conference Paper

We have developed a technology that facilitates the targeted delivery of glucocorticoids to arthritic joints thereby side-stepping systemic immune suppression while potentially improving efficacy. Our technology loads phototherapeutics inside of red blood cell (RBC) carriers. This ensures that the inactive, RBC-contained phototherapeutic drug is transported throughout the body and released from the RBC carrier only after triggered release by long-wavelength light. We have demonstrated that medications bound to vitamin B12 can be photo-released from RBCs using tissue penetrating, longwavelength red, far-red, and near infrared light in the collagen antibody-induced arthritis model.

Full Text

Duke Authors

Cited Authors

  • Wickenheisser, V; Zywot, EM; Rabjohns, E; Orlova, N; Marvin, CM; Ding, S; Lawrence, DS; Tarrant, TR

Published Date

  • January 1, 2020

Published In

Volume / Issue

  • 11223 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9781510632097

Digital Object Identifier (DOI)

  • 10.1117/12.2546949

Citation Source

  • Scopus