Photo-released drugs: A targeted treatment approach for arthritis
Conference Paper
We have developed a technology that facilitates the targeted delivery of glucocorticoids to arthritic joints thereby side-stepping systemic immune suppression while potentially improving efficacy. Our technology loads phototherapeutics inside of red blood cell (RBC) carriers. This ensures that the inactive, RBC-contained phototherapeutic drug is transported throughout the body and released from the RBC carrier only after triggered release by long-wavelength light. We have demonstrated that medications bound to vitamin B12 can be photo-released from RBCs using tissue penetrating, longwavelength red, far-red, and near infrared light in the collagen antibody-induced arthritis model.
Full Text
Duke Authors
Cited Authors
- Wickenheisser, V; Zywot, EM; Rabjohns, E; Orlova, N; Marvin, CM; Ding, S; Lawrence, DS; Tarrant, TR
Published Date
- January 1, 2020
Published In
Volume / Issue
- 11223 /
International Standard Serial Number (ISSN)
- 1605-7422
International Standard Book Number 13 (ISBN-13)
- 9781510632097
Digital Object Identifier (DOI)
- 10.1117/12.2546949
Citation Source
- Scopus