Anti-HIV tigliane diterpenoids from Reutealis trisperma.

Journal Article (Journal Article)

Bioassay-guided fractionation of the n-butanol extract from the branches and leaves of Reutealis trisperma resulted in the isolation of six undescribed (crotignoids L ~ Q) together with two known (12-deoxyphorbol-13-hexadecanoate and 12-deoxyphorbol-13-myristate) tigliane diterpenoids. Their structures, especially the absolute configurations, were determined from extensive spectroscopic studies, including 2D NMR spectra, CD data analysis and electronic circular dichroism (ECD) calculations. All isolates were tested for anti-HIV activity against HL4-3 virus in MT4 cells. Except for crotignoid Q, the remaining seven tigliane diterpenoids exhibited potent anti-HIV activity with IC50 values ranging from 0.0023 to 4.03 μM.

Full Text

Duke Authors

Cited Authors

  • Lu, Y; Huang, Y-S; Chen, C-H; Akiyama, T; Morris-Natschke, SL; Cheng, Y-Y; Chen, I-S; Yang, S-Z; Chen, D-F; Lee, K-H

Published Date

  • June 2020

Published In

Volume / Issue

  • 174 /

Start / End Page

  • 112360 -

PubMed ID

  • 32229336

Pubmed Central ID

  • PMC7238976

Electronic International Standard Serial Number (EISSN)

  • 1873-3700

Digital Object Identifier (DOI)

  • 10.1016/j.phytochem.2020.112360


  • eng

Conference Location

  • England