Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial.

Journal Article (Journal Article)

The current study explored whether patient characteristics predicted patterns of antidepressant use (i.e., never used, single episode of use, or two or more episodes) in a naturalistic follow-up. Participants in the child/adolescent multimodal (CAMS) extended long-term study. (n = 318) indicated medication use over the course of eight follow-up visits, 3-12 years after receiving treatment in CAMS. 40.6% of participants reported never using an antidepressant during follow-up, 41.4% reported a single episode of antidepressant use, and 18.0% reported multiple episodes of antidepressant use. Greater baseline anxiety severity marginally predicted a single episode of antidepressant use; baseline depression severity predicted multiple episodes of use. Reasons for discontinuing antidepressants included perceived ineffectiveness (31.8%), side effects (25.5%), and improvement in symptoms (18.5%). Exploratory analyses examined predictors of medication use. Findings suggest that antidepressant use is common among anxious youth, as is discontinuation of antidepressant use. Clinical implications and future directions are discussed.

Full Text

Duke Authors

Cited Authors

  • Kagan, ER; Frank, HE; Norris, LA; Palitz, SA; Chiappini, EA; Knepley, MJ; Crane, ME; Phillips, KE; Ginsburg, GS; Keeton, C; Albano, AM; Piacentini, J; Peris, T; Compton, S; Sakolsky, D; Birmaher, B; Kendall, PC

Published Date

  • February 2021

Published In

Volume / Issue

  • 52 / 1

Start / End Page

  • 41 - 48

PubMed ID

  • 32253545

Pubmed Central ID

  • PMC7541463

Electronic International Standard Serial Number (EISSN)

  • 1573-3327

Digital Object Identifier (DOI)

  • 10.1007/s10578-020-00983-w


  • eng

Conference Location

  • United States