Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk.

Journal Article (Journal Article;Review)

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD).

Full Text

Duke Authors

Cited Authors

  • Sinha, RA; Rajak, S; Singh, BK; Yen, PM

Published Date

  • March 31, 2020

Published In

Volume / Issue

  • 21 / 7

PubMed ID

  • 32244266

Pubmed Central ID

  • PMC7170715

Electronic International Standard Serial Number (EISSN)

  • 1422-0067

Digital Object Identifier (DOI)

  • 10.3390/ijms21072391


  • eng

Conference Location

  • Switzerland