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Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.

Publication ,  Journal Article
Chiang, C-H; Won, SM; Orsborn, AL; Yu, KJ; Trumpis, M; Bent, B; Wang, C; Xue, Y; Min, S; Woods, V; Yu, C; Kim, BH; Kim, SB; Huq, R; Li, J ...
Published in: Science translational medicine
April 2020

Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called "Neural Matrix," that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies.

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Published In

Science translational medicine

DOI

EISSN

1946-6242

ISSN

1946-6234

Publication Date

April 2020

Volume

12

Issue

538

Start / End Page

eaay4682

Related Subject Headings

  • Rodentia
  • Primates
  • Microelectrodes
  • Electrodes, Implanted
  • Brain Mapping
  • Brain
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
 

Citation

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Chiang, C.-H., Won, S. M., Orsborn, A. L., Yu, K. J., Trumpis, M., Bent, B., … Viventi, J. (2020). Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates. Science Translational Medicine, 12(538), eaay4682. https://doi.org/10.1126/scitranslmed.aay4682
Chiang, Chia-Han, Sang Min Won, Amy L. Orsborn, Ki Jun Yu, Michael Trumpis, Brinnae Bent, Charles Wang, et al. “Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.Science Translational Medicine 12, no. 538 (April 2020): eaay4682. https://doi.org/10.1126/scitranslmed.aay4682.
Chiang C-H, Won SM, Orsborn AL, Yu KJ, Trumpis M, Bent B, et al. Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates. Science translational medicine. 2020 Apr;12(538):eaay4682.
Chiang, Chia-Han, et al. “Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.Science Translational Medicine, vol. 12, no. 538, Apr. 2020, p. eaay4682. Epmc, doi:10.1126/scitranslmed.aay4682.
Chiang C-H, Won SM, Orsborn AL, Yu KJ, Trumpis M, Bent B, Wang C, Xue Y, Min S, Woods V, Yu C, Kim BH, Kim SB, Huq R, Li J, Seo KJ, Vitale F, Richardson A, Fang H, Huang Y, Shepard K, Pesaran B, Rogers JA, Viventi J. Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates. Science translational medicine. 2020 Apr;12(538):eaay4682.

Published In

Science translational medicine

DOI

EISSN

1946-6242

ISSN

1946-6234

Publication Date

April 2020

Volume

12

Issue

538

Start / End Page

eaay4682

Related Subject Headings

  • Rodentia
  • Primates
  • Microelectrodes
  • Electrodes, Implanted
  • Brain Mapping
  • Brain
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences