Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.
Journal Article (Journal Article)
PURPOSE: We performed a retrospective chart review on 393 patients with multiple myeloma (MM) to determine the utility of the gamma gap (GG). METHODS: We calculated the difference between a patient's total serum protein and albumin as a point-of-care test for assessing disease status in MM. RESULTS: GG is highly correlated with the level of M-spike, and the change in GG correlates with myeloma treatment response. In addition, fitted linear models were established that allow for the calculation of M-protein level from the GG within hours from blood draw. CONCLUSION: Our study has important implications in the care of MM, particularly in countries/areas with limited resources.
Full Text
Duke Authors
Cited Authors
- Dupuis, MM; Paul, B; Loitsch, G; Mathews, P; Feinberg, D; Barak, I; Li, Z; Tuchman, SA; Kang, Y
Published Date
- August 2020
Published In
- Jco Oncol Pract
Volume / Issue
- 16 / 8
Start / End Page
- e751 - e757
PubMed ID
- 32240071
Pubmed Central ID
- PMC7427420
Electronic International Standard Serial Number (EISSN)
- 2688-1535
Digital Object Identifier (DOI)
- 10.1200/JOP.19.00517
Language
- eng
Conference Location
- United States