Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.

Journal Article (Journal Article)

PURPOSE: We performed a retrospective chart review on 393 patients with multiple myeloma (MM) to determine the utility of the gamma gap (GG). METHODS: We calculated the difference between a patient's total serum protein and albumin as a point-of-care test for assessing disease status in MM. RESULTS: GG is highly correlated with the level of M-spike, and the change in GG correlates with myeloma treatment response. In addition, fitted linear models were established that allow for the calculation of M-protein level from the GG within hours from blood draw. CONCLUSION: Our study has important implications in the care of MM, particularly in countries/areas with limited resources.

Full Text

Duke Authors

Cited Authors

  • Dupuis, MM; Paul, B; Loitsch, G; Mathews, P; Feinberg, D; Barak, I; Li, Z; Tuchman, SA; Kang, Y

Published Date

  • August 2020

Published In

  • Jco Oncol Pract

Volume / Issue

  • 16 / 8

Start / End Page

  • e751 - e757

PubMed ID

  • 32240071

Pubmed Central ID

  • PMC7427420

Electronic International Standard Serial Number (EISSN)

  • 2688-1535

Digital Object Identifier (DOI)

  • 10.1200/JOP.19.00517


  • eng

Conference Location

  • United States