High-Flow Nasal Cannula versus Continuous Positive Airway Pressure in Critical Bronchiolitis: A Randomized Controlled Pilot

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Journal Article

AbstractWe conducted a randomized controlled pilot study in infants with critical bronchiolitis (n = 63) comparing high-flow nasal cannula (HFNC, n = 35) to continuous positive airway pressure (CPAP, n = 28). The primary outcome was treatment failure, defined as the need for bilevel positive pressure ventilation or endotracheal intubation. Treatment failure occurred in 10 patients (35.7%) in the CPAP group and 13 patients (37.1%) in the HFNC group (p = 0.88). Pediatric intensive care unit length of stay was similar between the CPAP and HFNC groups (5 [4–7] days and 5 [4–8] days, p = 0.46, respectively). In this pilot study, treatment with HFNC resulted in a rate of treatment failure similar to CPAP.

Full Text

Duke Authors

Cited Authors

  • Cesar, RG; Bispo, BRP; Felix, PHCA; Modolo, MCC; Souza, AAF; Horigoshi, NK; Rotta, AT

Published In

Published By

Electronic International Standard Serial Number (EISSN)

  • 2146-4626

International Standard Serial Number (ISSN)

  • 2146-4618

Digital Object Identifier (DOI)

  • 10.1055/s-0040-1709656


  • en