Skip to main content

Virtual clinical trials in medical imaging: a review.

Publication ,  Journal Article
Abadi, E; Segars, WP; Tsui, BMW; Kinahan, PE; Bottenus, N; Frangi, AF; Maidment, A; Lo, J; Samei, E
Published in: J Med Imaging (Bellingham)
July 2020

The accelerating complexity and variety of medical imaging devices and methods have outpaced the ability to evaluate and optimize their design and clinical use. This is a significant and increasing challenge for both scientific investigations and clinical applications. Evaluations would ideally be done using clinical imaging trials. These experiments, however, are often not practical due to ethical limitations, expense, time requirements, or lack of ground truth. Virtual clinical trials (VCTs) (also known as in silico imaging trials or virtual imaging trials) offer an alternative means to efficiently evaluate medical imaging technologies virtually. They do so by simulating the patients, imaging systems, and interpreters. The field of VCTs has been constantly advanced over the past decades in multiple areas. We summarize the major developments and current status of the field of VCTs in medical imaging. We review the core components of a VCT: computational phantoms, simulators of different imaging modalities, and interpretation models. We also highlight some of the applications of VCTs across various imaging modalities.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Med Imaging (Bellingham)

DOI

ISSN

2329-4302

Publication Date

July 2020

Volume

7

Issue

4

Start / End Page

042805

Location

United States

Related Subject Headings

  • 4003 Biomedical engineering
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abadi, E., Segars, W. P., Tsui, B. M. W., Kinahan, P. E., Bottenus, N., Frangi, A. F., … Samei, E. (2020). Virtual clinical trials in medical imaging: a review. J Med Imaging (Bellingham), 7(4), 042805. https://doi.org/10.1117/1.JMI.7.4.042805
Abadi, Ehsan, William P. Segars, Benjamin M. W. Tsui, Paul E. Kinahan, Nick Bottenus, Alejandro F. Frangi, Andrew Maidment, Joseph Lo, and Ehsan Samei. “Virtual clinical trials in medical imaging: a review.J Med Imaging (Bellingham) 7, no. 4 (July 2020): 042805. https://doi.org/10.1117/1.JMI.7.4.042805.
Abadi E, Segars WP, Tsui BMW, Kinahan PE, Bottenus N, Frangi AF, et al. Virtual clinical trials in medical imaging: a review. J Med Imaging (Bellingham). 2020 Jul;7(4):042805.
Abadi, Ehsan, et al. “Virtual clinical trials in medical imaging: a review.J Med Imaging (Bellingham), vol. 7, no. 4, July 2020, p. 042805. Pubmed, doi:10.1117/1.JMI.7.4.042805.
Abadi E, Segars WP, Tsui BMW, Kinahan PE, Bottenus N, Frangi AF, Maidment A, Lo J, Samei E. Virtual clinical trials in medical imaging: a review. J Med Imaging (Bellingham). 2020 Jul;7(4):042805.

Published In

J Med Imaging (Bellingham)

DOI

ISSN

2329-4302

Publication Date

July 2020

Volume

7

Issue

4

Start / End Page

042805

Location

United States

Related Subject Headings

  • 4003 Biomedical engineering
  • 3202 Clinical sciences