The enduring importance of family health history in the era of genomic medicine and risk assessment.


Journal Article

Improving disease risk prediction and tailoring preventive interventions to patient risk factors is one of the primary goals of precision medicine. Family health history is the traditional approach to quickly gather genetic and environmental data relevant to the patient. While the utility of family health history is well-documented, its utilization is variable, in part due to lack of patient and provider knowledge and incomplete or inaccurate data. With the advances and reduced costs of sequencing technologies, comprehensive sequencing tests can be performed as a risk assessment tool. We provide an overview of each of these risk assessment approaches, the benefits and limitations and implementation challenges.

Full Text

Duke Authors

Cited Authors

  • Haga, SB; Orlando, LA

Published Date

  • May 1, 2020

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 229 - 239

PubMed ID

  • 32320338

Pubmed Central ID

  • 32320338

Electronic International Standard Serial Number (EISSN)

  • 1744-828X

Digital Object Identifier (DOI)

  • 10.2217/pme-2019-0091


  • eng

Conference Location

  • England