Targeting Vascular Calcification in Chronic Kidney Disease.


Journal Article (Review)

Cardiovascular (CV) disease remains an important cause of morbidity and mortality for patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with CKD is well recognized, kidney-specific mechanisms are believed to drive the disproportionate burden of CV disease. One perturbation that is frequently observed at high rates in patients with CKD is vascular calcification, which may be a central mediator for an array of CV sequelae. This review summarizes the pathophysiological bases of intimal and medial vascular calcification in CKD, current strategies for diagnosis and management, and posits vascular calcification as a risk marker and therapeutic target.

Full Text

Duke Authors

Cited Authors

  • Nelson, AJ; Raggi, P; Wolf, M; Gold, AM; Chertow, GM; Roe, MT

Published Date

  • April 27, 2020

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 398 - 412

PubMed ID

  • 32368697

Pubmed Central ID

  • 32368697

Electronic International Standard Serial Number (EISSN)

  • 2452-302X

International Standard Serial Number (ISSN)

  • 2452-302X

Digital Object Identifier (DOI)

  • 10.1016/j.jacbts.2020.02.002


  • eng