Targeting Vascular Calcification in Chronic Kidney Disease.
Publication
, Journal Article
Nelson, AJ; Raggi, P; Wolf, M; Gold, AM; Chertow, GM; Roe, MT
Published in: JACC Basic Transl Sci
April 2020
Cardiovascular (CV) disease remains an important cause of morbidity and mortality for patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with CKD is well recognized, kidney-specific mechanisms are believed to drive the disproportionate burden of CV disease. One perturbation that is frequently observed at high rates in patients with CKD is vascular calcification, which may be a central mediator for an array of CV sequelae. This review summarizes the pathophysiological bases of intimal and medial vascular calcification in CKD, current strategies for diagnosis and management, and posits vascular calcification as a risk marker and therapeutic target.
Duke Scholars
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Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
April 2020
Volume
5
Issue
4
Start / End Page
398 / 412
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Nelson, A. J., Raggi, P., Wolf, M., Gold, A. M., Chertow, G. M., & Roe, M. T. (2020). Targeting Vascular Calcification in Chronic Kidney Disease. JACC Basic Transl Sci, 5(4), 398–412. https://doi.org/10.1016/j.jacbts.2020.02.002
Nelson, Adam J., Paolo Raggi, Myles Wolf, Alexander M. Gold, Glenn M. Chertow, and Matthew T. Roe. “Targeting Vascular Calcification in Chronic Kidney Disease.” JACC Basic Transl Sci 5, no. 4 (April 2020): 398–412. https://doi.org/10.1016/j.jacbts.2020.02.002.
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM, Roe MT. Targeting Vascular Calcification in Chronic Kidney Disease. JACC Basic Transl Sci. 2020 Apr;5(4):398–412.
Nelson, Adam J., et al. “Targeting Vascular Calcification in Chronic Kidney Disease.” JACC Basic Transl Sci, vol. 5, no. 4, Apr. 2020, pp. 398–412. Pubmed, doi:10.1016/j.jacbts.2020.02.002.
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM, Roe MT. Targeting Vascular Calcification in Chronic Kidney Disease. JACC Basic Transl Sci. 2020 Apr;5(4):398–412.
Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
April 2020
Volume
5
Issue
4
Start / End Page
398 / 412
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology