Ezrin Orchestrates Signal Transduction in Airway Cells.

Journal Article (Journal Article;Review)

Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth factor receptor (EGFR), CD44, vascular cell adhesion molecule (VCAM), and the deleted in colorectal cancer (DCC) receptor. We also analyze the ezrin-meditated regulation of critical pathways associated with asthma, such as the RhoA, Rho-associated protein kinase (ROCK), and protein kinase A (cAMP/PKA) pathways. Mounting evidence suggests that ezrin plays a role in controlling airway cell function and potentially contributes to respiratory diseases. Ezrin can participate in asthma pathogenesis by affecting bronchial epithelium repair, T lymphocyte regulation, and the contraction of the airway smooth muscle cells. These studies provide new insights for the design of novel therapeutic strategies for asthma treatment.

Full Text

Duke Authors

Cited Authors

  • Yin, L-M; Duan, T-T; Ulloa, L; Yang, Y-Q

Published Date

  • 2018

Published In

Volume / Issue

  • 174 /

Start / End Page

  • 1 - 23

PubMed ID

  • 28702704

Pubmed Central ID

  • PMC6289583

International Standard Serial Number (ISSN)

  • 0303-4240

Digital Object Identifier (DOI)

  • 10.1007/112_2017_4

Language

  • eng

Conference Location

  • Germany