S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle.

Journal Article (Journal Article)

Airway hyperresponsiveness (AHR) is a major clinical problem in allergic asthma mainly caused by the hypercontractility of airway smooth muscles (ASM). S100A8 is an important member of the S100 calcium-binding protein family with a potential to regulate cell contractility. Here, we analyze the potential of S100A8 to regulate allergen-induced AHR and ASM contraction. Treatment with recombinant S100A8 (rS100A8) diminished airway hyperresponsiveness in OVA-sensitized rats. ASM contraction assays showed that rS100A8 reduced hypercontractility in both isolated tracheal rings and primary ASM cells treated by acetylcholine. rS100A8 markedly rescued the phosphorylation level of myosin light chain induced by acetylcholine in ASM cells. These results show that rS100A8 plays a protective role in regulating AHR in asthma by inhibiting ASM contraction. These results support S100A8 as a novel therapeutic target to control ASM contraction in asthma.

Full Text

Duke Authors

Cited Authors

  • Xu, Y-D; Wang, Y; Yin, L-M; Park, G-H; Ulloa, L; Yang, Y-Q

Published Date

  • February 26, 2017

Published In

Volume / Issue

  • 484 / 1

Start / End Page

  • 184 - 188

PubMed ID

  • 28088518

Pubmed Central ID

  • 28088518

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2017.01.033

Language

  • eng

Conference Location

  • United States