α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

Published

Journal Article

Classically, sympathetic and parasympathetic systems act in opposition to maintain the physiological homeostasis. In this article, we report that both systems work together to restrain systemic inflammation in life-threatening conditions such as sepsis. This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. Unlike adrenalectomy, splenectomy and splenic neurectomy prevent the anti-inflammatory potential of both the vagus nerve and cholinergic agonists, and abrogate their potential to induce splenic and plasma norepinephrine. Splenic nerve stimulation mimics vagal and cholinergic induction of norepinephrine and re-establishes neuromodulation in α7 nicotinic acetylcholine receptor (α7nAChR)-deficient animals. Thus, vagus nerve and cholinergic agonists inhibit systemic inflammation by activating the noradrenergic splenic nerve via the α7nAChR nicotinic receptors. α7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation.

Full Text

Duke Authors

Cited Authors

  • Vida, G; Peña, G; Deitch, EA; Ulloa, L

Published Date

  • April 1, 2011

Published In

Volume / Issue

  • 186 / 7

Start / End Page

  • 4340 - 4346

PubMed ID

  • 21339364

Pubmed Central ID

  • 21339364

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1003722

Language

  • eng

Conference Location

  • United States