α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
Journal Article (Journal Article)
Classically, sympathetic and parasympathetic systems act in opposition to maintain the physiological homeostasis. In this article, we report that both systems work together to restrain systemic inflammation in life-threatening conditions such as sepsis. This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. Unlike adrenalectomy, splenectomy and splenic neurectomy prevent the anti-inflammatory potential of both the vagus nerve and cholinergic agonists, and abrogate their potential to induce splenic and plasma norepinephrine. Splenic nerve stimulation mimics vagal and cholinergic induction of norepinephrine and re-establishes neuromodulation in α7 nicotinic acetylcholine receptor (α7nAChR)-deficient animals. Thus, vagus nerve and cholinergic agonists inhibit systemic inflammation by activating the noradrenergic splenic nerve via the α7nAChR nicotinic receptors. α7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation.
Full Text
Duke Authors
Cited Authors
- Vida, G; Peña, G; Deitch, EA; Ulloa, L
Published Date
- April 1, 2011
Published In
Volume / Issue
- 186 / 7
Start / End Page
- 4340 - 4346
PubMed ID
- 21339364
Pubmed Central ID
- PMC3083451
Electronic International Standard Serial Number (EISSN)
- 1550-6606
Digital Object Identifier (DOI)
- 10.4049/jimmunol.1003722
Language
- eng
Conference Location
- United States