Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.

Journal Article

Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites. It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures. Here, we show that another microtubule associated protein, MAP1B, aberrantly phosphorylated by a proline-dependent protein kinase, is a component of these previously mentioned structures. Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD.

Full Text

Duke Authors

Cited Authors

  • Ulloa, L; Montejo de Garcini, E; Gómez-Ramos, P; Morán, MA; Avila, J

Published Date

  • October 1994

Published In

Volume / Issue

  • 26 / 1-2

Start / End Page

  • 113 - 122

PubMed ID

  • 7854037

Pubmed Central ID

  • 7854037

International Standard Serial Number (ISSN)

  • 0169-328X

Digital Object Identifier (DOI)

  • 10.1016/0169-328x(94)90081-7

Language

  • eng

Conference Location

  • Netherlands