Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.
Publication
, Journal Article
Ulloa, L; Montejo de Garcini, E; Gómez-Ramos, P; Morán, MA; Avila, J
Published in: Brain research. Molecular brain research
October 1994
Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites. It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures. Here, we show that another microtubule associated protein, MAP1B, aberrantly phosphorylated by a proline-dependent protein kinase, is a component of these previously mentioned structures. Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD.
Published In
Brain research. Molecular brain research
DOI
ISSN
0169-328X
Publication Date
October 1994
Volume
26
Issue
1-2
Start / End Page
113 / 122
Related Subject Headings
- tau Proteins
- Reference Values
- Rats
- Protein Serine-Threonine Kinases
- Proline-Directed Protein Kinases
- Phosphorylation
- Phosphoproteins
- Olfactory Bulb
- Neurology & Neurosurgery
- Neurofibrillary Tangles
Citation
APA
Chicago
ICMJE
MLA
NLM
Ulloa, L., Montejo de Garcini, E., Gómez-Ramos, P., Morán, M. A., & Avila, J. (1994). Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. Brain Research. Molecular Brain Research, 26(1–2), 113–122. https://doi.org/10.1016/0169-328x(94)90081-7
Ulloa, L., E. Montejo de Garcini, P. Gómez-Ramos, M. A. Morán, and J. Avila. “Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.” Brain Research. Molecular Brain Research 26, no. 1–2 (October 1994): 113–22. https://doi.org/10.1016/0169-328x(94)90081-7.
Ulloa L, Montejo de Garcini E, Gómez-Ramos P, Morán MA, Avila J. Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. Brain research Molecular brain research. 1994 Oct;26(1–2):113–22.
Ulloa, L., et al. “Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.” Brain Research. Molecular Brain Research, vol. 26, no. 1–2, Oct. 1994, pp. 113–22. Epmc, doi:10.1016/0169-328x(94)90081-7.
Ulloa L, Montejo de Garcini E, Gómez-Ramos P, Morán MA, Avila J. Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. Brain research Molecular brain research. 1994 Oct;26(1–2):113–122.
Published In
Brain research. Molecular brain research
DOI
ISSN
0169-328X
Publication Date
October 1994
Volume
26
Issue
1-2
Start / End Page
113 / 122
Related Subject Headings
- tau Proteins
- Reference Values
- Rats
- Protein Serine-Threonine Kinases
- Proline-Directed Protein Kinases
- Phosphorylation
- Phosphoproteins
- Olfactory Bulb
- Neurology & Neurosurgery
- Neurofibrillary Tangles