Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis.

Published

Journal Article

Stearoyl lysophosphatidylcholine (LPC) has recently been proven protective against lethal sepsis by stimulating neutrophils to eliminate invading pathogens through an H2O2-dependent mechanism. Here, we demonstrate that stearoyl LPC, but not caproyl LPC, significantly attenuates circulating high-mobility group box 1 (HMGB1) levels in endotoxemia and sepsis by suppressing endotoxin-induced HMGB1 release from macrophages/monocytes. Neutralizing antibodies against G2A, a potential cell surface receptor for LPC, partially abrogated stearoyl LPC-mediated suppression of HMGB1 release. Thus, stearoyl LPC confers protection against lethal experimental sepsis partly by facilitating the elimination of the invading pathogens and partly by inhibiting endotoxin-induced release of a late proinflammatory cytokine, HMGB1.

Full Text

Duke Authors

Cited Authors

  • Chen, G; Li, J; Qiang, X; Czura, CJ; Ochani, M; Ochani, K; Ulloa, L; Yang, H; Tracey, KJ; Wang, P; Sama, AE; Wang, H

Published Date

  • April 2005

Published In

Volume / Issue

  • 46 / 4

Start / End Page

  • 623 - 627

PubMed ID

  • 15687351

Pubmed Central ID

  • 15687351

International Standard Serial Number (ISSN)

  • 0022-2275

Digital Object Identifier (DOI)

  • 10.1194/jlr.C400018-JLR200

Language

  • eng

Conference Location

  • United States