Role of phosphorylated MAPlB in neuritogenesis.

Journal Article (Journal Article)

The distribution of microtubule-associated protein lB (MAPlB) phosphorylated by either proline-directed protein kinase (PDPK) or casein kinase II (CK II) in neuroblastoma cells and hippocampal neurons has been studied by immunofluorescence using specific antibodies to distinct phosphorylation-sensitive epitopes. A proximo-distal gradient of increasing PDPK-catalyzed phosphorylation of MAPlB is superimposed on a proximo distal gradient of decreasing CK II-catalyzed MAPlB phosphorylation within growing axon-like neurites. Additionally, CK II-phosphorylated MAPlB is present in cell bodies and dendrites where no PDPK-phosphorylated MAPlB is observed. These results suggest distinct roles for both types of modifications of MAPlB in developing neurons.

Full Text

Duke Authors

Cited Authors

  • Avila, J; Ulloa, L; Diez-Guerra, J; Diaz-Nido, J

Published Date

  • May 1994

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 309 - 314

PubMed ID

  • 7519512

International Standard Serial Number (ISSN)

  • 1065-6995

Digital Object Identifier (DOI)

  • 10.1006/cbir.1994.1079

Language

  • eng

Conference Location

  • England