Wnts and the hallmarks of cancer.
Publication
, Journal Article
Zhong, Z; Yu, J; Virshup, DM; Madan, B
Published in: Cancer Metastasis Rev
September 2020
Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in cancers have been extensively investigated. Activation of this evolutionarily conserved pathway promotes cancer development via diverse mechanisms. Cancer is a complex disease and one outstanding conceptual framework for understanding its biology is the "Hallmarks of Cancer". In this review, we focus on the involvement of Wnt signaling in the ten hallmarks of human cancer. These widespread roles of Wnt signaling in human cancers highlight the importance and feasibility of targeting this signaling pathway for cancer treatment.
Duke Scholars
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Published In
Cancer Metastasis Rev
DOI
EISSN
1573-7233
Publication Date
September 2020
Volume
39
Issue
3
Start / End Page
625 / 645
Location
Netherlands
Related Subject Headings
- Wnt Signaling Pathway
- Wnt Proteins
- Proto-Oncogene Mas
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Humans
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhong, Z., Yu, J., Virshup, D. M., & Madan, B. (2020). Wnts and the hallmarks of cancer. Cancer Metastasis Rev, 39(3), 625–645. https://doi.org/10.1007/s10555-020-09887-6
Zhong, Zheng, Jia Yu, David M. Virshup, and Babita Madan. “Wnts and the hallmarks of cancer.” Cancer Metastasis Rev 39, no. 3 (September 2020): 625–45. https://doi.org/10.1007/s10555-020-09887-6.
Zhong Z, Yu J, Virshup DM, Madan B. Wnts and the hallmarks of cancer. Cancer Metastasis Rev. 2020 Sep;39(3):625–45.
Zhong, Zheng, et al. “Wnts and the hallmarks of cancer.” Cancer Metastasis Rev, vol. 39, no. 3, Sept. 2020, pp. 625–45. Pubmed, doi:10.1007/s10555-020-09887-6.
Zhong Z, Yu J, Virshup DM, Madan B. Wnts and the hallmarks of cancer. Cancer Metastasis Rev. 2020 Sep;39(3):625–645.
Published In
Cancer Metastasis Rev
DOI
EISSN
1573-7233
Publication Date
September 2020
Volume
39
Issue
3
Start / End Page
625 / 645
Location
Netherlands
Related Subject Headings
- Wnt Signaling Pathway
- Wnt Proteins
- Proto-Oncogene Mas
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Humans
- Animals