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Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation.

Publication ,  Journal Article
Hildebrandt, GC; Chao, N
Published in: Br J Haematol
August 2020

Use of haematopoietic cell transplantation (HCT) in the treatment of haematologic and neoplastic diseases may lead to life-threatening complications that cause substantial morbidity and mortality if untreated. In addition to patient- and disease-related factors, toxicity associated with HCT puts patients at risk for complications that share a similar pathophysiology involving endothelial cells (ECs). Normally, the endothelium plays a role in maintaining homeostasis, including regulation of coagulation, vascular tone, permeability and inflammatory processes. When activated, ECs acquire cellular features that may lead to phenotypic changes that induce procoagulant, pro-inflammatory and pro-apoptotic mediators leading to EC dysfunction and damage. Elevated levels of coagulation factors, cytokines and adhesion molecules are indicative of endothelial dysfunction, and endothelial damage may lead to clinical signs and symptoms of pathological post-HCT conditions, including veno-occlusive disease/sinusoidal obstruction syndrome, graft-versus-host disease, transplant-associated thrombotic microangiopathy and idiopathic pneumonia syndrome/diffuse alveolar haemorrhage. The endothelium represents a rational target for preventing and treating HCT complications arising from EC dysfunction and damage. Additionally, markers of endothelial damage may be useful in improving diagnosis of HCT-related complications and monitoring treatment effect. Continued research to effectively manage EC activation, injury and dysfunction may be important in improving patient outcomes after HCT.

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Published In

Br J Haematol

DOI

EISSN

1365-2141

Publication Date

August 2020

Volume

190

Issue

4

Start / End Page

508 / 519

Location

England

Related Subject Headings

  • Transplantation Conditioning
  • Thrombotic Microangiopathies
  • Thrombophilia
  • Polydeoxyribonucleotides
  • Multiple Organ Failure
  • Inflammation
  • Immunotherapy, Adoptive
  • Immunology
  • Idiopathic Interstitial Pneumonias
  • Humans
 

Citation

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Hildebrandt, G. C., & Chao, N. (2020). Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation. Br J Haematol, 190(4), 508–519. https://doi.org/10.1111/bjh.16621
Hildebrandt, Gerhard C., and Nelson Chao. “Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation.Br J Haematol 190, no. 4 (August 2020): 508–19. https://doi.org/10.1111/bjh.16621.
Hildebrandt, Gerhard C., and Nelson Chao. “Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation.Br J Haematol, vol. 190, no. 4, Aug. 2020, pp. 508–19. Pubmed, doi:10.1111/bjh.16621.
Journal cover image

Published In

Br J Haematol

DOI

EISSN

1365-2141

Publication Date

August 2020

Volume

190

Issue

4

Start / End Page

508 / 519

Location

England

Related Subject Headings

  • Transplantation Conditioning
  • Thrombotic Microangiopathies
  • Thrombophilia
  • Polydeoxyribonucleotides
  • Multiple Organ Failure
  • Inflammation
  • Immunotherapy, Adoptive
  • Immunology
  • Idiopathic Interstitial Pneumonias
  • Humans