Bayesian Factor Analysis for Inference on Interactions.
Journal Article (Journal Article)
This article is motivated by the problem of inference on interactions among chemical exposures impacting human health outcomes. Chemicals often co-occur in the environment or in synthetic mixtures and as a result exposure levels can be highly correlated. We propose a latent factor joint model, which includes shared factors in both the predictor and response components while assuming conditional independence. By including a quadratic regression in the latent variables in the response component, we induce flexible dimension reduction in characterizing main effects and interactions. We propose a Bayesian approach to inference under this Factor analysis for INteractions (FIN) framework. Through appropriate modifications of the factor modeling structure, FIN can accommodate higher order interactions. We evaluate the performance using a simulation study and data from the National Health and Nutrition Examination Survey (NHANES). Code is available on GitHub.
Full Text
Duke Authors
Cited Authors
- Ferrari, F; Dunson, DB
Published Date
- January 2021
Published In
Volume / Issue
- 116 / 535
Start / End Page
- 1521 - 1532
PubMed ID
- 34898761
Pubmed Central ID
- PMC8654343
Electronic International Standard Serial Number (EISSN)
- 1537-274X
International Standard Serial Number (ISSN)
- 0162-1459
Digital Object Identifier (DOI)
- 10.1080/01621459.2020.1745813
Language
- eng