How Diffusion Impacts Cortical Protein Distribution in Yeasts.

Journal Article (Journal Article;Review)

Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.

Full Text

Duke Authors

Cited Authors

  • Moran, KD; Lew, DJ

Published Date

  • April 30, 2020

Published In

Volume / Issue

  • 9 / 5

PubMed ID

  • 32365827

Pubmed Central ID

  • PMC7291136

Electronic International Standard Serial Number (EISSN)

  • 2073-4409

Digital Object Identifier (DOI)

  • 10.3390/cells9051113


  • eng

Conference Location

  • Switzerland