Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.

Journal Article (Editorial)

A cluster of patients poisoned by herbal medicine in the 1990s revealed that aristolochic acid (AA) causes kidney failure and upper tract urothelial carcinoma (UTUC). Recent research demonstrated that this was not an isolated incident; on the contrary, AA exposure is widespread in East Asia. This editorial highlights research by Lu and colleagues that investigates clinical characteristics of AA and non-AA UTUCs from 90 patients in Beijing based on the AA mutational signature. The study also detected AA mutations in non-tumor tissue of AA exposed patients and showed that AA mutations can be detected in urine, which might form the basis for non-invasive tests for AA exposure.

Full Text

Duke Authors

Cited Authors

  • Boot, A; Jiang, N; Rozen, SG

Published Date

  • 2020

Published In

Volume / Issue

  • 10 / 12

Start / End Page

  • 5578 - 5580

PubMed ID

  • 32373232

Pubmed Central ID

  • PMC7196294

Electronic International Standard Serial Number (EISSN)

  • 1838-7640

Digital Object Identifier (DOI)

  • 10.7150/thno.46489


  • eng

Conference Location

  • Australia